FAAH initiates a positive feedback loop to promote lung adenocarcinoma progression through inhibition of ferroptosis - PubMed
5 hours ago
- #lung adenocarcinoma
- #ferroptosis
- #FAAH
- FAAH is upregulated in lung adenocarcinoma (LUAD) and correlates with poor patient prognosis.
- FAAH inhibits ferroptosis in LUAD cells by promoting STAT3 palmitoylation, leading to GPX4 activation and reduced lipid peroxide accumulation.
- A positive feedback loop exists where activated STAT3 enhances FAAH transcription, further suppressing ferroptosis.
- Targeting FAAH represses tumor growth and improves cisplatin's anti-tumor efficacy in vivo, suggesting therapeutic potential.