Reframing ME/CFS: toward a unified mechanistic model of chronic post-infectious diseases - PubMed
3 hours ago
- #post-infectious diseases
- #ME/CFS
- #biological mechanisms
- The article reframes ME/CFS as a disorder of impaired adaptive capacity within post-infectious disease biology.
- Highlights a shift from psychosocial to biological frameworks, influenced by advances from Long-COVID research.
- Identifies key mechanisms like persistent immune dysregulation, mitochondrial reprogramming, and endothelial dysfunction.
- Emphasizes that pathology in ME/CFS is state-dependent and revealed under physiological stress.
- Notes the historical lack of biomarkers and heterogeneous definitions, complicating mechanistic understanding.