Quantitative Swept-Source Optical Coherence Tomography Angiography Indicators of Neurovascular Dysfunction in Alzheimer Disease - PubMed
5 hours ago
- #Neurovascular Dysfunction
- #Alzheimer Disease
- #Optical Coherence Tomography Angiography
- The study investigates OCTA biomarkers (retinal vessel skeleton density [VSD], choriocapillaris flow deficit [CCFD], and ganglion cell complex [GCC] thickness) as potential noninvasive indicators for Alzheimer disease (AD) and cognitive impairment.
- Findings show GCC thickness was thinner in AD dementia compared to controls, CCFD was lower in mild cognitive impairment (MCI) than AD dementia but higher in AD dementia than controls, and VSD and CCFD were significantly associated with cognitive status in multivariable models.
- The results suggest distinct microvascular changes across cognitive stages, with VSD decreasing and CCFD showing a biphasic pattern, possibly indicating early compensatory hyperperfusion followed by perfusion failure in AD dementia.
- OCTA-derived biomarkers demonstrated good discrimination among cognitive states (area under the curve 0.72 to 0.87), supporting their potential as accessible tools for detecting neurodegeneration, though larger longitudinal studies are needed for validation.