USP1 driven mitotic dysregulation and PLK1 stabilization confer Lenvatinib resistance in hepatocellular carcinoma - PubMed
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- #USP1
- #HCC
- #Lenvatinib resistance
- USP1-driven mitotic dysregulation and PLK1 stabilization contribute to Lenvatinib resistance in hepatocellular carcinoma (HCC).
- The study was approved by the Ethics Committee of the Affiliated Hospital of Nantong University and the Animal Care and Use Committee of Nantong University.
- Key molecules involved include USP1, PLK1, STUB1, and chromosome misalignment.
- The research highlights potential mechanisms behind drug resistance in HCC treatment.
- The authors declare no competing interests.