Deep cervical lymphatic-venous anastomosis attenuates cognitive dysfunction and biomarker abnormalities in severe Alzheimer's disease: A prospective single-arm study - PubMed
3 months ago
- #Alzheimer's disease
- #biomarkers
- #cognitive function
- Deep cervical lymphatic-venous anastomosis (dcLVA) was studied for its efficacy in severe Alzheimer's disease (AD).
- 139 severe AD patients underwent dcLVA, with cognitive function and biomarkers evaluated over a 6-month follow-up.
- Postoperative improvements included modestly elevated Mini-Mental State Examination (MMSE) scores and reductions in ADL, NPI, NPI-D, and SDI scores.
- Biomarker analyses showed decreased CSF Aβ42, Aβ40, and p-Tau levels postoperatively, with increased plasma concentrations of these markers.
- No deaths or serious procedure-related adverse events occurred during the 6-month follow-up.
- dcLVA may offer clinical benefits in severe AD, including attenuation of neuropsychiatric dysfunctions and potential slowing of symptom progression.