Microglial Adaptations to Chronic Nicotine in the Cerebellum: Proteomic Evidence for Neuroimmune Vulnerability - PubMed
6 hours ago
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- #nicotine
- #neuroimmunity
- Chronic nicotine exposure affects microglial proteomes in the cerebellum, with sex-dependent responses observed.
- Males show enrichment in cytoskeletal and metabolic proteins, while females exhibit complement-protein adaptations following nicotine exposure.
- Nicotine-related adaptations in male microglial proteomes are linked to neurodisorders like Huntington's disease and ALS, for which smoking is a known risk factor.