Efficacy and safety of pharmacological treatments in borderline personality disorder: A systematic review and network meta-analysis - PubMed
3 months ago
- #pharmacological treatments
- #borderline personality disorder
- #meta-analysis
- Patients with borderline personality disorder (BPD) are over-represented in psychiatric services and have higher suicide mortality.
- A network meta-analysis evaluated 26 pharmacological treatments for BPD symptoms, comparing them with placebo or other agents.
- Topiramate, lamotrigine, and aripiprazole were most effective in reducing hostility, aggressiveness, and anger, with varying levels of evidence.
- Carbamazepine and asenapine improved impulsivity and emotional dysregulation, but with lower certainty of evidence.
- Alprazolam, methylphenidate, haloperidol, and valproate had low-certainty evidence and should not be prioritized for unselected BPD samples.
- Prescription should be individualized, focusing on specific indications like panic, comorbid ADHD, or transient psychotic features.