A conserved, immune-regulated peritrophin promotes Vibrio cholerae colonization of the arthropod intestine - PubMed
4 hours ago
- #Peritrophin-15a
- #Vibrio cholerae
- #arthropod intestine
- Vibrio cholerae is a human diarrheal pathogen that also associates with terrestrial and aquatic arthropods.
- The study uses Drosophila melanogaster to show V. cholerae adheres to the arthropod intestine and activates the enteroendocrine cell innate immune response, increasing tachykinin (Tk) expression.
- Tk promotes V. cholerae colonization of the arthropod intestine by influencing antimicrobial peptides, lipases, chitinases, and chitin-binding proteins like Peritrophin-15a (Peri-15a).
- Peri-15a interacts with chitin fibrils in the peritrophic matrix, a protective layer over the arthropod intestinal epithelium, and is essential for robust V. cholerae colonization.
- Peri-15a homologs are found in various terrestrial and aquatic organisms, suggesting a widespread mechanism for V. cholerae colonization.
- The study proposes that V. cholerae's activation of the enteroendocrine immune response and Peri-15a expression maximizes colonization in arthropod hosts.