Candesartan cilexetil disrupts methicillin-resistant Staphylococcus aureus membrane and potentiates gentamicin and polymyxin B activity - PubMed
5 hours ago
- #MRSA
- #Candesartan cilexetil
- #Antimicrobial Resistance
- Candesartan cilexetil (CC) shows potent anti-MRSA activity by disrupting bacterial membrane homeostasis.
- CC binds to lipid molecules, reduces membrane fluidity, and down-regulates genes and metabolites related to cell membrane and wall.
- Decreasing C20:0 fatty acids leads to CC resistance, which can be reversed by C20:0 supplementation.
- The tetrazole ring and ester carbonic acid of CC are critical for its antibacterial activity.
- CC enhances the effectiveness of aminoglycoside antibiotics like gentamicin and polymyxin B against MRSA.
- In vivo studies show CC reduces MRSA replication in a murine abscess model, suggesting its potential as an antimicrobial agent or potentiator.