Fetal-restricted hematopoietic progenitors arise from hemogenic endothelium in vitelline and umbilical arteries - PubMed
6 hours ago
- #hematopoiesis
- #hemogenic endothelium
- #fetal development
- Fetal-restricted hematopoietic stem and progenitor cells (HSPCs) emerge from hemogenic endothelium in the vitelline and umbilical arteries between embryonic days 8.5 and 9.5 in mice.
- These progenitors are transient, distinct from erythro-myeloid progenitors, and contribute significantly to fetal lympho-myelopoiesis but decline after birth.
- The discovery identifies a previously unrecognized early wave of hemogenic endothelium as a key source of fetal-restricted HSPCs, enhancing understanding of layered hematopoiesis and blood cell diversity origins.