Fructose-1,6-bisphosphate couples glycolytic activity to cell adhesion - PubMed
6 hours ago
- #cell adhesion
- #glycolysis
- #Rac1 signaling
- Fructose-1,6-bisphosphate (FBP) links glycolytic activity to cell adhesion.
- Aldolase A, a glycolytic enzyme, acts as a regulatory switch connecting metabolic flux to focal adhesion (FA) assembly and cell morphogenesis.
- FBP serves as a signaling metabolite, transmitting metabolic state information to the actin-based machinery for cell adhesion and protrusion.
- FBP binds to the Rac1 inhibitor RCC2, elevating Rac1 activity, leading to actin reorganization, increased FA assembly, and protrusive activity.
- This mechanism is significant for processes ranging from development to cancer.