Associations of Life-Course Social Isolation Trajectories and Depressive Symptoms With the Risk of Incident Cardiovascular Disease: A Prospective Cohort Study - PubMed
5 hours ago
- #social isolation
- #depressive symptoms
- #cardiovascular disease
- Four distinct life-course social isolation trajectories were identified: no isolation, childhood-only, adulthood-only, and persistent isolation.
- Persistent social isolation was associated with significantly elevated odds of incident cardiovascular disease (CVD) (OR = 1.53, 95% CI: 1.16-2.01).
- Depressive symptoms accounted for a meaningful proportion of the association between persistent isolation and CVD, mediating 16.28% of the relationship.
- Childhood social isolation, childhood-only isolation, and persistent isolation were each independently associated with increased odds of incident stroke.
- The study underscores the importance of incorporating long-term psychosocial assessments into CVD risk stratification and management strategies.