Beyond sex determination: the Y chromosome in male cancers - PubMed
3 hours ago
- #Y Chromosome
- #Cancer Research
- #Genomic Alterations
- Loss of the Y chromosome (LOY) is the most common somatic genomic alteration in males, linked to aging, environmental exposures, and genetic factors.
- LOY is associated with cancer susceptibility, progression, and poor outcomes in various cancer types, including haematological malignancies and solid tumors.
- Y-chromosome genes play roles in male development, transcriptional regulation, chromatin remodeling, immune signaling, and androgen signaling, impacting cancer biology.
- Functional studies suggest LOY affects immune surveillance, DNA repair, metabolism, and the tumor immune microenvironment, with context-dependent roles in cancer.
- Advanced sequencing and LOY scoring algorithms enable precise monitoring, offering potential as a biomarker for cancer risk, immunotherapy response, and precision therapy.