Jieduquyuziyin prescription for systemic lupus erythematosus: a system-level therapeutic strategy for immunological recalibration - PubMed
4 hours ago
- #Immunomodulation
- #Systemic Lupus Erythematosus
- #Traditional Chinese Medicine
- The Jieduquyuziyin prescription (JP) is a Chinese herbal formula that shows clinical efficacy in treating Systemic Lupus Erythematosus (SLE).
- Clinical trials indicate JP reduces SLEDAI scores, alleviates lupus nephritis, lowers glucocorticoid needs, and improves patient quality of life.
- Preclinical studies in SLE models reveal JP restores immune balance by regulating Th17/Treg cells, suppressing pathogenic B cells, and promoting apoptosis of abnormal T cells.
- JP targets multiple pathways, including inhibiting macrophage IRAK1/NF-κB signaling and activating renal FXR to reduce fibrosis in lupus nephritis.
- It addresses metabolic dysfunction by reversing glycolytic reprogramming in lymphocytes via AMPK signaling and restoring mitochondrial function.
- JP also remodels gut microbiota, enriching beneficial bacteria like Akkermansia and modulating metabolites to support immune homeostasis.
- The review validates JP as a system-level therapeutic strategy aligning with TCM principles and modern immunology for SLE treatment.