Bone regeneration, tendon fiber formation, and angiogenesis are enhanced by the multifaceted effects of biodegradable octacalcium phosphate and gelatin scaffold materials - PubMed
4 hours ago
- #Tissue regeneration
- #Biodegradable materials
- #Octacalcium phosphate
- Octacalcium phosphate (OCP) enhances bone regeneration, tendon fiber formation, and angiogenesis.
- OCP activates various bone-related cells, including osteoblasts, osteocytes, and endothelial cells.
- OCP cannot be sintered due to water molecules but can be improved with gelatin as a matrix material.
- OCP/gelatin composite improves bone defect repair, tendon insertion, and angiogenesis in animal models.
- OCP/gelatin induces woven bone formation, a precursor to mineralized bone, compared to β-TCP.
- OCP's multifaceted effects propose a new principle in biomaterials science for tissue regeneration.
- The study highlights OCP's potential in regenerating multiple tissues, including enthesis and vascularization.