Inflammatory ILC2s migrate to distal tissues during infection using stage-specific S1P receptors - PubMed
5 hours ago
- #ILC2s
- #immune migration
- #S1P receptors
- Inflammatory ILC2s (iILC2s) migrate from the intestine to distal tissues during helminth infection.
- Migration requires access to lymphatic vessels and is regulated by IL-25-induced epigenetic changes.
- Transcription factors KLF2 and ZEB2 drive expression of S1PR1 and S1PR5, respectively.
- S1PR5 regulates iILC2 exit from the intestine to lymph, while S1PR1 is critical for egress from lymph nodes to blood and distal tissues like the lung.
- Dynamic CD69 expression mediates S1PR1 internalization, necessitating two S1PRs for stage-specific migration.
- iILC2s contribute to tissue repair in distal tissues such as the lung.