Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages - PubMed
3 hours ago
- #inflammatory bowel disease
- #psoriasis
- #lipid metabolism
- Patients with psoriasis have an increased risk of developing inflammatory bowel disease (IBD).
- Psoriasis severity inversely correlates with postprandial plasma apolipoprotein B48 levels, indicating impaired intestinal lipid handling.
- A recombinant photoconvertible apolipoprotein B reporter was developed to quantify chylomicron production in real-time.
- Psoriasis promotes the expansion of IL-1β-producing intestinal macrophages, which impair chylomicron secretion and drive epithelial lipid accumulation.
- Macrophage-driven metabolic dysregulation links psoriasis to gut inflammation, with intestinal IL-1β identified as a potential therapeutic target.