Cardiovascular risk assessment characterized by proteomics in cancer survivors - PubMed
5 hours ago
- #proteomics
- #cardiovascular risk
- #cancer survivors
- Classic cardiovascular disease risk scores perform poorly in cancer survivors, prompting a search for better biomarkers.
- A study of 4225 UK Biobank cancer survivors linked 182 plasma proteins to major CVD risk, with key proteins including NTproBNP, NPC2, TNFRSF12A, LMNB2, and EDA2R involved in immune, inflammatory, and angiogenesis processes.
- A 23-protein panel developed via random forest modeling showed moderate predictive performance for CVDs and outperformed traditional risk scores, improving discrimination and risk reclassification when added to existing scores.