Auricular Vagus Nerve Stimulation Alleviates Cardiac Dysfunction in Takotsubo Syndrome by Inhibiting Excessive Activation of the Sympathetic Nerve System and Inflammation - PubMed
7 days ago
- #Takotsubo Syndrome
- #Vagus Nerve Stimulation
- #Inflammation
- Auricular vagus nerve stimulation (taVNS) improves cardiac function in Takotsubo syndrome (TTS) by reducing sympathetic overactivation and inflammation.
- Study conducted on Sprague-Dawley rats with TTS induced by isoprenaline; taVNS applied for 1 hour.
- taVNS significantly reduced arrhythmia susceptibility, myocardial injury, and collagen reaction in TTS rats.
- taVNS suppressed sympathetic overactivation and systemic inflammation, with the TLR2/MAPK pathway identified as a key mediator.
- Findings suggest taVNS as a promising adjunct therapy for TTS, offering benefits in inflammation control and heart stability.