Bnip3lb-driven mitophagy maintains fate of the embryonic hematopoietic stem cell pool - PubMed
6 hours ago
- #mitophagy
- #hematopoiesis
- #stem_cells
- Embryonic hematopoietic stem and progenitor cells (HSPCs) maintain multipotency while undergoing proliferative expansion.
- Bnip3lb-driven mitophagy regulates reactive oxygen species (ROS) to sustain HSPC fate during development.
- Mitophagy initiates during endothelial-to-hematopoietic transition and colonization of secondary niches in zebrafish.
- Loss of bnip3lb reduces mitophagy, leading to myeloid-biased differentiation and apoptosis in HSPCs.
- Mitophagy induction enhances embryonic HSPC and lymphoid progenitor numbers.
- Chemical activation of mitophagy improves ex vivo function of human-induced pluripotent stem cell-derived HSPCs.
- The study highlights a distinct autophagic mechanism in embryonic HSPCs compared to adult HSPCs.