miR‑223‑3p promotes microglial lactylation and M1 polarization via the FBXW7/Notch1/Hes1/SIRT1 axis - PubMed
2 days ago
- #Alzheimer's disease
- #Microglial polarization
- #Neuroinflammation
- miR‑223‑3p is upregulated in Alzheimer's disease patients and promotes microglial M1 polarization and ROS production.
- It enhances glycolysis, lactate production, and lactylation, with lactylation inhibition reducing M1 polarization and ROS.
- miR‑223‑3p targets FBXW7, activating the Notch1/Hes1 pathway and suppressing SIRT1 expression.
- This axis drives lactylation-mediated neuroinflammation, highlighting miR‑223‑3p as a potential therapeutic target for AD.