Antibody cocktails based on the occupationally acquired immunity of pediatricians neutralize and confer protection against RSV and hMPV - PubMed
4 days ago
- #monoclonal antibodies
- #RSV
- #hMPV
- Antibody cocktails derived from pediatricians' immunity neutralize RSV and hMPV.
- Monoclonal antibodies (mAbs) CNR2056 and CNR2053 neutralize diverse RSV strains.
- mAb CNR2047 uniquely cross-neutralizes RSV and hMPV variants.
- Prophylactic use of CNR2056 and CNR2053 reduces viral loads and pathology in RSV-infected cotton rats.
- CNR2047 provides complete lung protection against hMPV in mice at 0.5 mg/kg.
- Structural analysis reveals unique binding modes for the mAbs, aiding rational cocktail design.
- Mutations to evade CNR2053 and CNR2056 are in evolutionarily constrained sites, suggesting a fitness cost.
- Combining site Ø- and site III-directed mAbs (e.g., CNR2056-CNR2047) enhances coverage and minimizes escape risks.
- Cocktails of CNR2056, CNR2053, and CNR2047 may offer broad protection against current and future pneumoviruses.