Increased CSF levels of soluble AXL at diagnosis correlate with poor prognosis in patients affected by amyotrophic lateral sclerosis - PubMed
6 hours ago
- #amyotrophic lateral sclerosis
- #biomarker
- #neurodegeneration
- Elevated CSF soluble AXL (sAXL) levels at diagnosis are linked to worse prognosis in ALS patients.
- sAXL, a receptor tyrosine kinase involved in neuronal survival and immune regulation, shows alterations in ALS biofluids.
- The study measured sAXL in CSF and serum from ALS patients, healthy controls, and other neurological disorders.
- CSF sAXL levels correlate with disease progression and have prognostic value for ALS stratification.
- Findings suggest the AXL pathway's role in ALS pathology, supporting sAXL as a potential biomarker.