Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis - PubMed
4 hours ago
- #mechanobiology
- #endothelial cells
- #pulmonary fibrosis
- Single-cell multiomics reveals a mechanosensitive PIEZO1-IL-33 axis in endothelial cells driving pulmonary fibrosis.
- Pulmonary fibrosis is characterized by excessive extracellular matrix deposition and lung tissue distortion.
- Endothelial cells contribute to fibrosis through pro-fibrotic mediator secretion, regulated by mechanobiology.
- PIEZO1 upregulation in endothelial cells is identified as a hallmark of fibrotic progression.
- Endothelial-specific PIEZO1 knockout in mice reduces bleomycin-induced fibrosis, confirming its pathogenic role.
- PIEZO1 activation promotes fibrosis via CAPN2-mediated STAT3 phosphorylation, regulating interleukin-33 secretion.
- The PIEZO1-CAPN2-STAT3-IL33 axis is a potential therapeutic target for pulmonary fibrosis.