Thoracic perivascular adipose tissue-derived PI16 alleviates vascular calcification via CKAP4/PI3K/Akt pathway - PubMed
3 hours ago
- #Chronic kidney disease
- #Vascular calcification
- #Perivascular adipose tissue
- Thoracic perivascular adipose tissue (tPVAT) protects against medial arterial calcification, a complication of chronic kidney disease.
- PI16, derived from tPVAT fibroblasts, is identified as a key anti-calcific factor that inhibits vascular smooth muscle cell calcification.
- PI16 interacts with cytoskeleton-associated protein 4 (CKAP4) on vascular smooth muscle cells, suppressing the PI3K/Akt/RUNX2 pathway and osteogenic differentiation.
- Transplantation of tPVAT or use of recombinant PI16 attenuated aortic calcification in experimental models, suggesting a potential therapeutic target.