AML-Targeted Metal-Polyphenol Nanoplatform Induces Ferroptosis-ICD Cascade for Antitumor Immunity Boosting - PubMed
11 hours ago
- #Nanoplatform
- #AML
- #Immunotherapy
- Development of a ferritin-based nanoplatform (Fe-SH@Fn) targeting AML cells by leveraging CD71 overexpression.
- Co-delivery of shikonin (SH) and Fe3+ to induce ferroptosis and immunogenic cell death (ICD) synergistically.
- Mechanism involves glutathione-triggered disassembly of Fe-SH@Fn, leading to Fe2+-mediated Fenton reaction and SH-induced ICD.
- Enhanced antitumor immunity through dendritic cell maturation, increased CD8+ T cell infiltration, and reduced regulatory T cells.
- In vivo results show 81.25% tumor growth inhibition and 2.8-fold increase in median survival in AML models without systemic toxicity.
- Potential translatable strategy to overcome AML immunosuppression via targeted drug delivery and ferroptosis-ICD activation.