HR3/RORα-mediated cholesterol sensing regulates TOR signaling - PubMed
10 hours ago
- #nuclear receptor
- #TOR signaling
- #cholesterol sensing
- Cholesterol availability regulates cell and organism growth, but sensing mechanisms are unclear.
- Cholesterol rapidly activates the TOR growth pathway in Drosophila; nuclear receptor HR3 (RORα ortholog) is essential for this.
- HR3 binds cholesterol and activates TOR via a non-genomic mechanism upstream of Rag GTPases, while also modulating longer-term genomic responses.
- RORα is also required for cholesterol-mediated TOR activation in human cells, indicating a conserved cholesterol-sensing mechanism.
- Findings enhance understanding of cholesterol's role in growth, with relevance to cholesterol-related diseases and cancer.