Targeting MUC16 Suppresses Malignant Progression and Chemoresistance in Large-duct Type Intrahepatic Cholangiocarcinoma - PubMed
5 hours ago
- #chemoresistance
- #MUC16
- #cholangiocarcinoma
- MUC16 is identified as a key molecular marker in large-duct type intrahepatic cholangiocarcinoma (L-iCCA).
- Targeting MUC16 inhibits L-iCCA cell proliferation and migration.
- OSMI-1, a small-molecule compound, suppresses MUC16 expression and disrupts the OGT-IRF1 transcriptional complex.
- OSMI-1 synergizes with gemcitabine to effectively inhibit L-iCCA growth in mouse models.
- The study provides a precision therapeutic strategy for L-iCCA based on pathological subtyping.