Unraveling Diabetic Cardiomyopathy (DCM): The Critical Role of the Yap-miR-22-3p-Sirt1 Axis in the Pathogenesis of DCM - PubMed
5 hours ago
- #Yap-miR-22-3p-Sirt1 Axis
- #Diabetic Cardiomyopathy
- #Cardiovascular Disease
- Diabetic cardiomyopathy (DCM) is a condition where diabetes causes abnormalities in myocardial structure and function.
- Yes-associated protein (Yap) is associated with cardiovascular diseases and affects heart remodeling and function, but its role in DCM was unclear.
- High glucose or high glucose plus palmitic acid increases Yap activity, which promotes miR-22-3p expression and inhibits Sirt1 expression.
- The Yap-miR-22-3p-Sirt1 axis is crucial in the development of DCM.
- The study identifies potential therapeutic targets for DCM and suggests new treatment strategies for diabetic cardiac dysfunction.