Identification of novel bioactive constituents from traditional decoction of jiao-tai-Wan based on "co-decoction reaction" and comparative analysis with formula granules - PubMed
11 hours ago
- #co-decoction reaction
- #diabetes mellitus
- #formula granules
- Study investigates therapeutic equivalence between formula granules and traditional co-decoction using Jiao-Tai-Wan in diabetic mice.
- Identifies 29 new co-decoction-related compounds using UPLC-QE-Orbitrap-MS.
- Co-decoction showed the most pronounced reduction in fasting blood glucose, followed by mixed decoction and formula granules.
- Different preparations distinctly modulated gut microbiota in db/db mice.
- Strong binding confirmed between main constituents (e.g., berberine, cinnamic acid) and taste receptors (TAS2R46, TRPV1).
- Findings suggest co-decoction reaction products may explain efficacy differences between formula granules and traditional decoctions.