Transcriptional profiles of antidepressant resistance across the corticolimbic pathway of chronically stressed mice - PubMed
5 hours ago
- #depression
- #neuroscience
- #antidepressant-resistance
- Study focuses on treatment-resistant depression (TRD) in mice exposed to chronic social defeat stress.
- Mice were treated with fluoxetine (FLX) and ketamine (KET), showing varied responses.
- RNA sequencing revealed transcriptional differences in the nucleus accumbens (NAc) and prefrontal cortex (PFC) between responders and non-responders.
- FLX exposure had a priming effect, enhancing KET responsiveness in some mice but not in non-responders.
- Gene co-expression analysis identified unique modules for stress susceptibility and antidepressant resistance.
- Findings suggest that failed treatments alter molecular landscapes, affecting subsequent treatment outcomes.
- Research provides insights into molecular mechanisms of TRD and potential therapeutic strategies.