NRH attenuates age-related hearing loss by suppressing cochlear ferroptosis and cellular senescence via Sirt3 activation - PubMed
5 hours ago
- #Cochlear health
- #Age-related hearing loss
- #NAD+ precursor
- NRH (Dihydronicotinamide riboside) attenuates age-related hearing loss (ARHL) in C57BL/6 mice.
- NRH administration improves auditory thresholds and elevates cochlear NAD+ levels.
- NRH preserves cochlear hair cells, synapses, and auditory neurons.
- Mechanistically, NRH activates Sirt3, inhibiting oxidative stress and lipid peroxidation via ferroptosis-related pathways.
- NRH demonstrates a favorable safety profile and temporal distribution in cochlear cell types.
- The study suggests NRH has significant translational potential for ARHL treatment.