Systematic assessment of obesity-related risk factors in renal cancer etiology: A longitudinal risk and mendelian randomization analysis - PubMed
3 months ago
- #obesity
- #Mendelian randomization
- #renal cancer
- Excess body adiposity is an established cause of renal cancer, but underlying molecular pathways remain unclear.
- The study evaluated obesity-related risk factors using longitudinal cohort analysis and Mendelian randomization (MR).
- Key findings include positive associations between renal cancer risk and fasting insulin, triglycerides, and diastolic blood pressure (DBP).
- Inverse associations were found with sex-hormone binding globulin (SHBG) and high-density lipoprotein (HDL) cholesterol.
- The study highlights roles for fasting insulin, HDL cholesterol, DBP, triglycerides, and SHBG in mediating the relationship between body adiposity and renal cancer risk.
- A limitation was limited statistical power to evaluate some risk factors.