Association of Smoking and Alcohol Consumption with Female Reproductive Diseases: A Mendelian Randomization Study on the Mediating Role of Circulating Metabolites - PubMed
5 hours ago
- #female reproductive health
- #smoking and metabolites
- #Mendelian randomization
- Study investigates causal links between smoking/alcohol and female reproductive diseases using Mendelian randomization.
- Smoking initiation linked to higher risks of abnormal uterine bleeding, endometrioid ovarian cancer, ovarian cysts, and pelvic inflammatory diseases.
- Higher cigarette consumption causally associated with increased adenomyosis risk.
- Mediation analysis identifies inflammatory and lipid-related metabolites (e.g., GlycA, VLDL) as partial mediators of smoking effects.
- Triglycerides in lipoprotein subclasses mediate a small percentage of smoking's impact on reproductive inflammatory diseases.
- Findings suggest metabolic dysregulation as a target for risk stratification and smoking prevention strategies.