Mitochondrial dysfunction and disrupted neuronal lipid homeostasis in Parkinson's disease: Potential mechanisms and therapeutic implications - PubMed
6 hours ago
- #Parkinson's disease
- #Mitochondrial dysfunction
- #Lipid homeostasis
- Parkinson's disease (PD) is characterized by dopaminergic neuron loss and alpha-synuclein accumulation.
- Mitochondrial dysfunction and disrupted lipid homeostasis are central to PD pathogenesis.
- Key pathological mechanisms include ferroptosis, alpha-synuclein-lipid interactions, mitochondrial dysfunction, and impaired autophagy/mitophagy.
- These mechanisms lead to oxidative stress, membrane destabilization, and bioenergetic collapse.
- Therapeutic strategies targeting iron accumulation, lipid peroxidation, and alpha-synuclein aggregation show promise.
- Further research is needed to clarify interactions and develop disease-modifying interventions.