IL1β+ macrophages promote intestinal fibrosis in Crohn's disease by secreting AREG to activate PI16+ fibroblasts - PubMed
6 hours ago
- #intestinal fibrosis
- #macrophages
- #Crohn's disease
- IL1β+ macrophages promote intestinal fibrosis in Crohn's disease by secreting AREG to activate PI16+ fibroblasts.
- The study was approved by the Institutional Ethics Committee of the Sixth Affiliated Hospital of Sun Yat-sen University (2020ZSLYEC-257).
- Animal experiments were conducted in accordance with ARRIVE 2.0 guidelines and Chinese Standard GB 14925 − 2023.
- No competing financial or personal interests were declared by the authors.
- References include studies on the worldwide incidence and prevalence of inflammatory bowel disease (IBD) and management of intestinal fibrosis in IBD patients.