Receptor-binding specificity and antigenic properties of a genotype D1.1 A(H5N1) influenza virus isolated from a human - PubMed
6 hours ago
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- #H5N1
- #influenza
- Study focuses on receptor-binding specificity and antigenic properties of genotype D1.1 A(H5N1) influenza virus from a human case.
- Clade 2.3.4.4b A(H5N1) viruses are expanding host range, raising public health concerns.
- Human infection case in British Columbia involved genotype D1.1 A(H5N1) with HA substitutions.
- Research aimed to monitor receptor-binding and antigenicity of emerging A(H5N1) variants for human adaptation risks.
- HA-variant subpopulations were enriched to assess sialic acid receptor usage via multiple assays.
- All tested variants bound exclusively to avian-type sialic acid receptors, showing no human-type receptor preference.
- Antigenicity of the A(H5N1) variants was covered by existing candidate vaccine viruses.