Pyrroloquinoline quinone alleviates age-related osteoarthritis via nuclear factor erythroid 2-related factor 2-mediated stress response and insulin-like growth factor 1 receptor upregulation - PubMed
6 hours ago
- #IGF1R
- #Osteoarthritis
- #Nrf2
- Pyrroloquinoline quinone (PQQ) alleviates age-related osteoarthritis (OA) by activating Nrf2-mediated antioxidant responses and upregulating IGF1R.
- Long-term dietary PQQ in mice reduced OA symptoms, preserved cartilage, and decreased oxidative damage and senescence markers.
- PQQ enhanced Nrf2 nuclear accumulation and antioxidant gene expression, with IGF1R identified as a direct Nrf2 target.
- The study suggests the PQQ-Nrf2-IGF1R axis as a therapeutic target for age-related OA.