Time- and risk-dependent effects of dual antiplatelet therapy targeting the P2Y12 receptor after CABG: A network meta-analysis of graft permeability and clinical outcomes - PubMed
4 hours ago
- #coronary artery bypass grafting
- #network meta-analysis
- #dual antiplatelet therapy
- Dual antiplatelet therapy (DAPT) with aspirin plus clopidogrel or ticagrelor significantly reduces saphenous vein graft occlusion compared to aspirin monotherapy.
- Aspirin plus ticagrelor and rivaroxaban monotherapy increase the risk of major bleeding compared to aspirin.
- No antithrombotic strategy significantly impacts myocardial infarction or all-cause mortality; subgroup analyses show DAPT benefits in off-pump CABG and early initiation.