Statin Induced New-onset Diabetes Mellitus - A Narrative Review - PubMed
14 hours ago
- #Statin
- #Cardiovascular disease
- #New-onset diabetes mellitus
- Statins are widely used to lower LDL cholesterol and prevent cardiovascular disease.
- There is increasing evidence that statins may increase the risk of new-onset diabetes mellitus (NODM).
- High-intensity statins like atorvastatin and rosuvastatin carry a greater diabetes risk compared to pravastatin or pitavastatin.
- Proposed mechanisms include increased insulin resistance, impaired insulin secretion, and changes in hepatic glucose production.
- Despite the diabetes risk, the cardiovascular benefits of statins generally outweigh this concern.
- The review discusses evidence on statin use and NODM, mechanisms, diabetogenic effects of different statins, and clinical implications.