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Case Report: Infant with vaccine-associated paralytic poliomyelitis unveils global disparities in care for inborn errors of immunity - PubMed

4 hours ago
  • #Healthcare Disparity
  • #SCID
  • #VAPP
  • Case report of an Indonesian infant with severe combined immunodeficiency (SCID) and Omenn syndrome.
  • Infant developed vaccine-associated paralytic poliomyelitis (VAPP) after receiving oral polio vaccine (OPV).
  • Diagnosis delayed due to limited diagnostic capabilities in resource-limited settings.
  • Highlights the need for improved diagnostic tools and transition from OPV to inactivated polio vaccine (IPV).
  • Emphasizes the importance of newborn screening (NBS) for SCID in lower to middle income countries.
  • Child passed away at 8 months due to febrile illness; family opted for palliative care over HSCT.