Melatonin safeguards against butylparaben-induced oxidative stress, DNA damage, microtubule instability, and organelle dysfunction during porcine oocyte maturation - PubMed
6 hours ago
- #Butylparaben
- #Melatonin
- #Oocyte-maturation
- Butylparaben (BP) exposure impairs cumulus cell expansion, oocyte nuclear maturation, and embryonic development.
- BP causes abnormalities in microtubule structure, actin-mediated cytoskeleton dynamics, and organelle dysfunction (mitochondria, endoplasmic reticulum, lipid metabolism).
- BP induces oxidative stress, DNA damage, and cell death by interfering with DNA double-strand break repair.
- Melatonin (MLT) supplementation mitigates BP-induced meiotic and developmental defects in porcine oocytes.
- MLT protects oocytes by preventing nuclear and cytoplasmic maturation failure caused by BP.
- The study suggests MLT as a potential therapeutic strategy to improve oocyte quality and fertility.