Associations of antidiabetic medications with abdominal aortic aneurysm growth and clinical outcomes: A systematic review and meta-analysis - PubMed
5 hours ago
- #Meta-Analysis
- #Antidiabetic Medications
- #Abdominal Aortic Aneurysm
- Metformin is associated with slower AAA growth (-0.65 mm/year) and lower AAA-related events (OR 0.63).
- Sulfonylureas reduce AAA growth (-0.35 mm/year) and AAA-related events (OR 0.63).
- DPP-4 inhibitors show no significant effect on AAA growth, and metformin has no significant link to postoperative mortality.
- Most evidence comes from observational studies with moderate bias, limiting causal conclusions.
- Randomized trials are needed to confirm drug-specific effects across patient groups.