Physiological Regulation of Nutritional and Metabolic Biomarkers in Obesity: Implications for Precision Nutrition - PubMed
6 hours ago
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- #obesity-research
- Obesity is a heterogeneous metabolic disorder with significant individual variation in inflammatory status, insulin sensitivity, and cardiometabolic risk.
- Traditional measures like anthropometrics are inadequate for capturing metabolic diversity, hindering personalized interventions.
- Key biomarkers in obesity include adipokines (e.g., leptin, adiponectin), inflammatory markers (e.g., CRP, IL-6), insulin resistance indices (e.g., HOMA-IR), and lipid metabolism indicators (e.g., LDL, triglycerides, liver enzymes).
- Elevated CRP, reduced adiponectin, and increased HOMA-IR show strong clinical utility for early metabolic risk detection.
- Emerging biomarkers like circulating microRNAs, gut microbiota metabolites (e.g., SCFAs, TMAO), and bile acid profiles offer deeper insights into diet-microbiome-host interactions.
- Dietary composition, including fatty acid quality, fiber intake, and patterns like the Mediterranean diet, influences biomarker profiles and metabolic health.
- Precision nutrition can be advanced by biomarker-based phenotyping to tailor dietary interventions for individuals.
- Integrating multi-biomarker panels with clinical and genetic data is key to moving from population guidelines to personalized nutrition strategies.