Endurance exercise relieves methamphetamine craving behaviors via hepatic synthesis of N-Acetylneuraminic acid - PubMed
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- #endurance exercise
- #liver-brain axis
- #methamphetamine addiction
- Endurance exercise reduces methamphetamine (METH) craving behaviors, supporting drug abstinence and rehabilitation.
- A 48-week aerobic exercise program in METH addicts increased serum levels of N-Acetylneuraminic acid (Neu5Ac).
- Exercise promotes hepatic synthesis of Neu5Ac, which modulates striatal synaptic proteins to decrease METH-seeking behaviors.
- The mechanism involves a liver-brain axis where exercise-induced liver metabolism changes alleviate addiction-related behaviors.