Scientists Cloned a Mouse for 58 Generations. The Results Were Catastrophic
6 hours ago
- #Reproductive Science
- #Cloning Research
- #Genetic Mutations
- A 20-year mouse cloning experiment showed that repeated cloning across 58 generations led to accumulating mutations, eventually making clones inviable.
- Genetic abnormalities began affecting fertility after generation 25, and by generation 58, cloned mice died shortly after birth, despite no initial issues in appearance or lifespan.
- Researchers found that the mutations were in the DNA sequence, not due to epigenetic changes or cloning enhancers like Trichostatin A losing effectiveness.
- The study raises doubts about using cloning to save endangered mammal species, highlighting that sexual reproduction is essential for long-term mammalian survival.
- While cloning works in some non-mammals (e.g., hydra, coral), mammals face biological constraints that prevent indefinite cloning without genetic degradation.