Interlaboratory exercise on the use of immunofluorescence microscopy on the blood smear for recognizing inherited platelet disorders: Communication from the ISTH SSC Subcommittee on Platelets in Healt
4 days ago
- #inherited platelet disorders
- #immunofluorescence microscopy
- #diagnostic validation
- Immunofluorescence microscopy on blood smears is a promising method for diagnosing inherited platelet disorders (IPD).
- An interlaboratory study validated the reproducibility of this method across seven laboratories.
- High diagnostic accuracy was achieved for MYH9-related disease, Bernard-Soulier syndrome, Glanzmann thrombasthenia, and GFI1B-related thrombocytopenia.
- Reasonable sensitivity was observed for TUBB1-related disorder, quantitative δ-storage pool disorder, and GATA1-related thrombocytopenia.
- The method may be useful in the diagnostic work-up of IPD.