Identification of cis-regulatory elements provides insights into tissue-specific gene regulation in the sheep genome - PubMed
6 hours ago
- #sheep genome
- #gene regulation
- #enhancers
- Identification of 274,682 enhancers and 25,975 promoters across 24 sheep tissues using multiple sequencing techniques.
- Discovery of seven neural development-related genes with over 10 enhancers in brain tissues, emphasizing tissue-specific regulation.
- Identification of a cerebellum-specific enhancer regulating BDNF, expressed in both cerebellum and cerebral cortex.
- Comparative analysis reveals ruminant-specific pathways, including pentose catabolism and long-chain fatty acid import regulation.
- A milk fat yield QTL interacts with the fat metabolism-related gene COMMD1.
- A birth weight-associated QTL within a cerebellum-specific enhancer regulates XKR4.
- Provides a framework for exploring cis-regulatory mechanisms and tissue-specific gene regulation in sheep.