Deciphering the multidrug resistance paradigm in Candida auris - PubMed
6 hours ago
- #public health
- #Candida auris
- #antifungal resistance
- Candida auris is a significant public health concern due to its widespread antifungal resistance.
- Most isolates are resistant to fluconazole, with some showing resistance to all clinically available antifungals.
- Resistance mechanisms vary by drug class, with fluconazole resistance driven by mutations in drug targets and efflux regulators.
- Echinocandins, amphotericin B, and flucytosine resistance is rare but can emerge under therapy.
- Amphotericin B resistance in C. auris is higher than in other Candida species, possibly due to intrinsic mechanisms.
- Understanding resistance mechanisms may improve therapeutic strategies for treating C. auris infections.