Randomized trial of GvHD Prophylaxis in Haploidentical PBSC Transplantation: ATG, PTCy, and Low-Dose Combination Therapy - PubMed
6 hours ago
- #GvHD prophylaxis
- #haploidentical transplantation
- #randomized trial
- Randomized trial comparing three GvHD prophylaxis strategies in haploidentical PBSCT: low-dose ATG/PTCy, standard-dose ATG, and PTCy.
- No significant differences in grade II-IV acute GvHD incidence by day 100 among the three groups.
- Moderate-to-severe chronic GvHD was numerically lower in ATG/PTCy and ATG groups compared to PTCy, but not statistically significant.
- No significant differences in survival outcomes observed across the three groups.
- ATG/PTCy group showed significantly higher rates of neutrophil and platelet recovery compared to other groups.
- All three prophylaxis strategies demonstrated similar efficacy in preventing grade II-IV acute GvHD and comparable survival outcomes.